Metallothionein - Wikipedia
WEBMetallothionein (MT) is an indirect redox balance regulator which regulates nuclear factor red blood cell 2-related factor 2 (Nrf2) in the body. However, MT plays an important role in the anti-injury protection of the cardiovascular system, mainly in its inhibitory effect on ischemia-reperfusion injury.
Metallothionein: the multipurpose protein - PubMed
WEBMetallothioneins (MTs) are intracellular, low molecular, low molecular weight, cysteine-rich proteins. Ubiquitous in eukaryotes, MTs have unique structural characteristics to give potent metal-binding and redox capabilities.
Metallothionein: A Comprehensive Review of Its Classification ...
WEBJul 9, 2024 · Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
The Role of Metallothionein in Oxidative Stress - PMC
WEBMar 15, 2013 · In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed.
Metallothioneins: Emerging Modulators in Immunity and Infection
WEBOct 23, 2017 · Metallothioneins (MTs) are a family of metal-binding proteins virtually expressed in all organisms including prokaryotes, lower eukaryotes, invertebrates and mammals. These proteins regulate homeostasis of zinc (Zn) and copper (Cu), mitigate heavy metal poisoning, and alleviate superoxide stress.
Metallothionein - an overview | ScienceDirect Topics
WEBMetallothioneins are small proteins that bind to heavy metals such as cadmium, zinc, and copper. They are rich in sulfhydryl groups and can be found in various tissues, including the liver, kidney, and intestine.
Metallothioneins: Diverse Protein Family to Bind Metallic Ions
WEBNov 3, 2021 · Metallothionein’s (MTs) are the lower molecular weight (6-7 kDa) proteins that are found to be present in almost all organism types ranging from prokaryotes to eukaryotes species. MT are the metal detecting proteins that can mitigate the effect caused by the excess metal ions.
The roles of metallothioneins in carcinogenesis
WEBAug 23, 2018 · Metallothioneins (MTs) are small cysteine-rich proteins that play important roles in metal homeostasis and protection against heavy metal toxicity, DNA damage, and oxidative stress. In humans, MTs have four main isoforms (MT1, MT2, MT3, and MT4) that are encoded by genes located on chromosome 16q13.
Metallothionein: A Comprehensive Review of Its Classification
WEBJul 9, 2024 · Metallothionein is a cysteine-rich protein with a high metal content that is widely found in nature. In addition to heavy metal detoxification, metallothionein is well known as a potent antioxidant.
The Enigmatic Metallothioneins: A Case of Upward-Looking …
WEBJun 1, 2021 · In the mid-1950s, Bert Lester Vallee and his colleague Marvin Margoshes discovered a molecule referred to today as metallothionein (MT). Meanwhile, MTs have been shown to be common in many biological organisms. Despite their prevalence, however, it remains unclear to date what exactly MTs do and how …