Four pillars of heart failure: contemporary ... - Open Heart
WEBThe past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF).1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
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WEBOpen Heart is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial ...
The health benefits of vitamin K - Open Heart
WEBIntroduction. Vitamin K is a fat-soluble vitamin, important for the function of numerous proteins within the body, such as the coagulation factors (II, VII, IX, X and protein C and protein S), osteocalcin (a bone-forming protein) and matrix-Gla protein (MGP) (an anticalcification protein), to name a few.1–3 Vitamin K exists naturally as vitamin K 1 (phylloquinone) and vitamin K 2 ...
Vitamin K2—a neglected player in cardiovascular health: a …
WEBVitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including increased arterial stiffness, vascular and valvular ...
Harnessing the power of clinical decision support systems: …
WEBClinical decision support systems (CDSSs) are increasingly integrated into healthcare settings to improve patient outcomes, reduce medical errors and enhance clinical efficiency by providing clinicians with evidence-based recommendations at the point of care. However, the adoption and optimisation of these systems remain a challenge. This review aims to provide an overview of the current state ...
On-X versus St Jude Medical Regent mechanical aortic valve …
WEBObjective We aimed to compare the early haemodynamic data of the On-X and St Jude Medical (SJM) Regent bileaflet mechanical prostheses in the aortic position. Methods A retrospective study was performed using data collected prospectively for a national database. Thirty-three patients who had aortic On-X valve (On-X group) and 33 matched patients who had aortic SJM Regent valve (SJM group) were ...
Acute myocarditis caused by COVID-19 disease and following …
WEBCOVID-19: from subclinical myocardial injury to fulminant lethal myocarditis. SARS-CoV-2 gains entry into human cells by binding its cleaved spike protein (S1/S2 and S2ʹ sites) to the ACE2 membrane protein,1 which, can be found on ciliated columnar epithelial cells of the respiratory tract, type II pneumocytes and also cardiomyocytes.2 Since, failed human hearts have a higher percentage of ...
Myo-inositol for insulin resistance, metabolic syndrome, polycystic ...
WEBMyo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups.1 For a long time, it was considered a B vitamin (vitamin B8). However, it is not considered an essential nutrient because it is formed from glucose. Each kidney makes around 2 g of myo-inositol per day, and the average dietary intake is 0.5–1.0 g/day.2 3 The liver and brain also ...
Transcatheter mitral valve repair: an overview of current and future ...
WEBThe field of transcatheter mitral valve repair (TMVr) for mitral regurgitation (MR) is rapidly evolving. Besides the well-established transcatheter mitral edge-to-edge repair approach, there is also growing evidence for therapeutic strategies targeting the mitral annulus and mitral valve chordae. A patient-tailored approach, careful patient selection and an experienced interventional team is ...
Cardiogenic shock: evolving definitions and future directions in ...
WEBCardiogenic shock (CS) is a complex and highly morbid entity conceptualised as a vicious cycle of injury, cardiac and systemic decompensation, and further injury and decompensation. The pathophysiology of CS is incompletely understood but limited clinical trial experience suggests that early and robust support of the failing heart to allow for restoration of systemic homoeostasis appears ...