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Duloxetine for treating painful neuropathy, chronic pain or
WEBThe usual dose of duloxetine is 60 mg. At this dose, there was moderate quality evidence that duloxetine reduced pain in both painful diabetic peripheral neuropathy and fibromyalgia. In diabetic peripheral neuropathic pain, a 50% or better improvement with duloxetine 60 mg per day was just over one and a half times more likely than with placebo.
Oral painkillers available without prescription for acute pain
WEBNon-prescription (over-the-counter, or OTC) analgesics (painkillers) are used frequently. They are available in various brands, package sizes, formulations, and dose. They can be used for a range of different types of pain, but this overview reports on how well they work for acute pain (pain of short duration, usually with rapid onset).
What are systematic reviews? - Cochrane
WEBCochrane evidence, including our systematic reviews, provides a powerful tool to enhance your healthcare knowledge and decision making. This video from Cochrane Sweden explains a bit about how we create health evidence and …
Amitriptyline for neuropathic pain in adults - Cochrane
WEBAmitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage). It is recommended as a first line treatment in many guidelines. Neuropathic pain can be treated with antidepressant drugs in doses below those at which the drugs act as antidepressants.
Bupropion for attention deficit hyperactivity disorder (ADHD
WEBBupropion may be an alternative treatment for adults with ADHD who cannot or will not take stimulant drugs. Quality of the evidence. The quality of the evidence in this review is low, because we found very few studies; five of the six studies were small, and all were poorly conducted. The effect of bupropion on various aspects of daily ...
New Cochrane Handbook for Systematic Reviews of Interventions
WEBThe new edition of the Handbook is divided into four parts. The first section (available only online) addresses issues specific to working with Cochrane. The second describes the core methods applicable to systematic reviews of interventions, from framing the question through to interpreting the results. The third and fourth parts address ...
Stopping blood pressure medications in older people | Cochrane
WEBPeople in the studies had an average age of 58 to 82 years. In three of the studies, the dose of the antihypertensive was slowly lowered before stopping. Key results. We found that stopping antihypertensive medications is possible in older adults. Most of the older people in the discontinuation groups did not need to restart their medication.
What are the benefits and risks of giving corticosteroids to …
WEBWe used standard Cochrane Pregnancy and Childbirth methods for data collection and analysis. Two review authors independently assessed trials for inclusion, assessed risk of bias, evaluated trustworthiness based on predefined criteria developed by Cochrane Pregnancy and Childbirth, extracted data and checked them for accuracy, and assessed …
What are the benefits and risks of surgery for epiretinal ... - Cochrane
WEBWe used standard methods expected by Cochrane, and assessed certainty using the GRADE system. We considered the following five outcome measures: mean change in best corrected visual acuity (BCVA) in the study eye between baseline (before randomisation), 6 months and 12 months later; proportion of people with a gain of 0.3 logMAR or more of …
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