We developed an assay of T cell activation involving stimulation of highly purified CD4 + T cells with immobilized antibodies against CD3/CD28, in the presence or absence of blocking monomeric Fab ...

To maintain tissue homeostasis under the duress of infection or injury, the immune system is endowed with a diverse repertoire of soluble and cellular effectors. The innate response, composed of ...

T cells are the 'foot soldiers' that fight cancer inside the body. Cancer cells can fight the foot soldiers back by pushing a brake on the T cells that will turn them off. This 'brake' is a molecule ...

No significant financial relationships to disclose. This is an ASCO Meeting Abstract from the 2009 ASCO Annual Meeting I. This abstract does not include a full text component.

As professional antigen presenting cells, dendritic cells balance immune activation and inhibition to maintain immune homeostasis. An important inhibitory molecule expressed by dendritic cells is ...