Sox9, a master regulator of cartilage formation, switches its target genes dynamically during embryonic limb development instead of following a fixed program, as reported by researchers from Science ...

Researchers have identified modes of Sox9 action during cartilage formation by analyzing big data on Sox9 location, chromatin state, and gene expression over the whole mouse genome. This finding will ...

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after ...

Osteochondral defects, often caused by injury or various pathologies, typically lead to the onset of osteoarthritis, and may ultimately result in the comprehensive degradation of the joint and ...

Cartilage is largely composed of a single type of cells, called chondrocytes and various types of extracellular matrix proteins including highly sulfated macromolecule proteoglycans, small ...

In patients with severe osteoarthritis, cartilage can wear so thin that joints essentially transform into bone on bone — without a cushion between. A new therapy that uses synthetic nanofibers to ...

A recent article in Engineering describes the development of a protein-based nanocomposite hydrogel designed to deliver two therapeutic agents—dexamethasone (Dex) and kartogenin (KGN)—to support ...

A new therapy that first made headlines in 2021 is now showing potential to heal human cartilage. Developed by scientists at Northwestern University, the technique was initially created to repair ...

Expedition 74 crew members aboard the International Space Station are 3D-printing viable human cartilage tissues inside the ...