N-terminal acetylation is an abundant and predominantly co-translational modification in eukaryotes that profoundly affects folding, compartmentalization fidelity and turnover of target proteins.

The alternative text for this image may have been generated using AI. In the ER, the composition of glycans is dynamic as they are modified depending on the folded state of the nascent chain to which ...

"They also point to a larger field of research emerging in my lab: the question of how NAC integrates co-translational targeting, enzymatic modification, protein folding, and assembly into a ...

Researchers at Baylor College of Medicine have developed an artificial intelligence (AI) model that reveals how protein modifications link genetic mutations to disease. The method, called DeepMVP and ...

Lactylation, a recently identified post-translational modification, has emerged as important for immune regulation, tissue repair, cancer cell metabolism, and now, potentially, Alzheimer’s disease. In ...

An AI model that reveals how protein modifications link genetic mutations to disease has been developed. Researchers at Baylor College of Medicine (TX, USA) have developed an AI model that reveals how ...