Anticoagulant treatments are crucial for managing many conditions, such as heart disease, stroke and venous thrombosis. Current options, however, carry an inherent risk of serious bleeding due to ...

A completely novel way to develop 'surpamolecules' for drug discovery could have application in immunotherapy as well as this breakthrough design for an anticoagulant with on-demand reversibility.

Panel A shows thrombin generation, and Panel B shows thrombin inhibition. Examples of the in vitro curves for thrombin generation and inhibition are also shown. Procoagulant factors are represented by ...

Please provide your email address to receive an email when new articles are posted on . Target-specific oral anticoagulants have emerged as alternative therapeutic options for the management of ...

Anticoagulant treatments are crucial for managing many conditions, such as heart disease, stroke and venous thrombosis. Current options, however, carry an inherent risk of serious bleeding due to ...

Patients with coronavirus disease 2019 (Covid-19) have a profound hypercoagulable state, and complicating venous thrombotic events are common. 1-3 Abnormalities in coagulation screening measures, ...

An increase in coagulation in patients with pancreatic carcinoma has long been documented. In this Review, we present what is known about the pathophysiology of increased coagulation in cancer and how ...

The image illustrate the combined action of two molecules cooperating to inhibit thrombin. The antidote dissociates the two molecules, preventing the cooperativity. The association and dissociation of ...