Epigenetic modifications such as DNA methylation play a key role in regulating gene expression. Emerging evidence suggests ...
Epigenetic modifications such as DNA methylation play a key role in regulating gene expression. Emerging evidence suggests ...
Cytosine and adenine base editors (CBEs and ABEs) are promising new tools for achieving the precise genetic changes required for disease treatment and trait improvement. However, genome-wide and ...
Cytosine and adenosine base editors (CBEs and ABEs) are integral to molecular breeding, enable precise modification of single-nucleotide polymorphisms (SNPs) in plants, which are crucial for agronomic ...
This is a preview. Log in through your library . Abstract The mechanism of DNA cytosine-5-methylation catalyzed by the bacterial M.Hhal enzyme has been considered as a stepwise nucleophilic addition ...
The DNA base cytosine has a lot of different outfits in its closet. Most famously, the base can slip on a methyl group at its fifth carbon, a change that lends cytosine the ability to silence genes.
Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...
It’s time to turn to sequencing the epigenome, the DNA modifications that alter gene expression and determine our individual genetic identity. DNA molecule with methylation on the center cytosine ...
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