Researchers at the MRC Laboratory of Medical Sciences (LMS) and collaborators have uncovered one of the earliest steps in DNA replication: the moment a cell first opens its DNA to begin making a copy ...

DNA replication and repair mechanisms constitute the foundation of genomic integrity, ensuring that genetic information is faithfully duplicated and maintained across cell generations. Replication ...

Cells have evolved careful checks to ensure DNA is copied only once, but how they switch on replication at the right moment has been the focus of a 30-year research question. New work from the Crick ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...