The contribution of genetics to the variability in people’s metabolism has remained largely unknown. This is, in part, because genetic studies of human metabolism have been limited in scale and ...

Many disease-associated variants are thought to be regulatory but are not present in existing catalogues of expression quantitative trait loci (eQTL). We hypothesise that these variants may regulate ...

A new study, published today in Nature Genetics, created the largest genetic map of human metabolism, revealing new insights on the role of metabolites in health and disease and creating a blueprint ...

For decades, geneticists have known that most common illnesses are not caused by a single rogue gene but by intricate constellations of DNA variants acting together in specific cells. Now a new ...

An illustration of multicolored tangle of threads within a small black sphere. A 3D illustration shows DNA packaged into the nucleus, scientists with the 4D Nucleome project are now building accurate ...

A central goal of human genetics is to learn how genetic variants impact the cellular and molecular phenotypes that underpin human diseases. Genetically engineered mouse models (GEMMs) are commonly ...

A gene can vanish, and life can go on. That is one of the most striking lessons from a sweeping new analysis of 173,303 ...

Researchers at the University of California San Diego have completed a massive genetic study that identifies key biological ...

At the turn of the century, the biomedical research community saw a landmark global effort, when scientists built a reference human genome sequence to better understand the genes underlying health and ...