The drug ibrutinib makes a covalent bond to Bruton's tyrosine kinase, an important cancer target. Credit: RCSB PDB/Yang H. Ku Enticing atoms to share their electrons—to make a covalent bond, in other ...
BUFFALO, N.Y. — One class of drugs that has shown promise in treating diseases ranging from lung cancer to COVID-19 are targeted covalent inhibitors (TCIs). These small molecule drugs form covalent ...
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