When most small-molecule drugs meet a protein target, they nestle close to their intended. But the flirtatious relationship between drug and target is often fleeting, with the drug repeatedly drifting ...

Prior to 2000, many drugs that formed a covalent bond with targets did so non-selectively, which often led to undesired side effects when compared to non-covalent drugs. This led to the belief that ...

Researchers at Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences compared three different drug delivery models based on ionic liquids. Scientists have developed a powerful API-IL ...

A research team from Hokkaido University has confirmed a century-old theory by discovering a stable single-electron covalent bond, known as a sigma bond, between two carbon atoms. This unique bond ...