8-oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G > T substitutions. Determinants of local and regional differences in 8-oxoG-induced mutability across genomes are currently unknown ...
Aging is a critical risk factor for cancer development with genetic instability presenting as a common hallmark. Alternative DNA-forming sequences are endogenous sources of genetic instability that ...
Radiation-induced mutation is unlikely to have induced genetic differences between dog populations in Chornobyl (or Chernobyl) City and the nearby Chornobyl Nuclear Power Plant (NPP), according to a ...
For nearly 40 years, the Chernobyl exclusion zone (CEZ) has been a laboratory for scientists to study the long-term effects of radiation exposure. One of the ongoing subjects in this unintentional ...
The first systematic whole genome sequencing study of how chemotherapy damages healthy tissues has shown that many, but not all, of these agents cause mutations and premature aging of normal blood ...
Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in ...
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