Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...

An important study published in JAMA Psychiatry (2025) challenges some of the most popular narratives about ketamine ’s ...

For the nearly 30 percent of major depressive disorder patients who are resistant to treatment, ketamine provides some amount of normalcy, but it requires frequent treatment and can have side effects.

The findings add to growing evidence that dissociation is not a necessary mechanism for ketamine’s antidepressant activity and that oral, prolonged-release formulations can mitigate key tolerability ...