The mevalonate pathway is central to the biosynthesis of isoprenoids and sterols, underpinning a range of essential cellular processes. Farnesyl diphosphate synthase (FPPS) is a pivotal enzyme in this ...

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair. Research at the ...

The shortage of geranylgeranyl-pyrophosphate (GGPP) was associated to an increased IL-1β release in the autoinflammatory syndrome mevalonate kinase deficiency (MKD), a rare inherited disease that has ...

Schematic diagram of mouse embryonic development on the indicated days. Bottom: The mevalonate pathway produces farnesyl diphosphate for cholesterol synthesis, protein geranylgeranylation and protein ...

Increased risk of MDS/AML post radiation treatment for breast cancer: Analysis of SEER data 2001-2008. This is an ASCO Meeting Abstract from the 2012 ASCO Annual Meeting I. This abstract does not ...

Physician perspectives on extrapolating data from trials testing less-intense treatment to underrepresented populations. Socioeconomic disparities in supportive therapy use and tolerance of aromatase ...

The team demonstrated for the first time that atorvastatin can directly attack liver cancer cells by blocking the " mevalonate pathway," a metabolic route crucial for cancer cell survival. This ...

CHAPEL HILL, N.C. – Researchers at the UNC School of Medicine, UNC McAllister Heart Institute, and the UNC Lineberger Comprehensive Cancer Center characterized the expression of thousands of cardiac ...

Mesotheliomas are highly aggressive cancers with short overall survival, which can be extended only by a few months with currently approved therapies. Around 60%-70% of malignant mesotheliomas present ...

What Is Mevalonate Kinase Deficiency? Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen glands, ...