Nature

Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases

The initial study group included 13 OC patients staged II-IV (International Federation of Gynecology and Obstetrics classification). All identified cases were ultimately found to be HGSOC.
ascopubs.org

Germ-line BRCA mutations in high-grade ovarian cancer: A case for routine BRCA mutation screening after a diagnosis of invasive ovarian cancer.

Sequence specific effects on DNA and cell damage with the PARP inhibitor olaparib (AZD2281) and carboplatin. This is an ASCO Meeting Abstract from the 2011 ASCO Annual Meeting I. This abstract does ...
Nature

Small-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer

A capture-based targeted sequencing panel was previously designed to analyse the exons of 63 genes (Supplementary Table 1) implicated in DNA repair or chemotherapy resistance in HGSC 18. Targeted ...
ascopubs.org

Underestimation of Risk of a BRCA1 or BRCA2 Mutation in Women With High-Grade Serous Ovarian Cancer by BRCAPRO: A Multi-Institution Study

Prolonged Administration of Azacitidine With or Without Entinostat for Myelodysplastic Syndrome and Acute Myeloid Leukemia With Myelodysplasia-Related Changes: Results of the US Leukemia Intergroup ...