NFL Week 10 betting spreads, lines, point totals for every game on NFL Week 10 schedule, with odds for favorites and underdogs in each NFL matchup.

Toby Mergler makes early Week 10 picks wildly over-indexing on vibes, small sample sizes and comparisons to pop culture classics.

Well, favorites have rolled the last two weeks, and that has led to some inflated spreads in Week 9 and more potential for some favorites to fall short of expectations, which has the ability to affect their Week 10 spreads as well.

The Chiefs have head-to-head losses to the Los Angeles Chargers and Jacksonville Jaguars, the two teams directly ahead of it in the wild-card standings. Patrick Mahomes and Co. still have to play the Denver Broncos twice, with the first meeting coming out of Kansas City's bye in Week 11.

The 49ers have suffered several injuries, yet they are still finding convincing ways to win, and they always play Sean McVay and his Rams tough. Keep an eye out for the line to move as the 49ers may get healthier by Sunday, they may even get back starting quarterback Brock Purdy.

After two bad weeks, it's back to the winning ways for me with my NFL picks. I went 9-4 against the spread last week and 10-3 straight up. That's my kind of week. It ups my season records to 64-57 ATS and 86-34-1 straight up.