Kansas City is a 2.5-point favorite in the latest Chiefs vs. Bills odds from SportsLine consensus, while the over-under for total points scored is 52.5. Kansas City is at -136 on the money line. Before making any Bills vs.

Get the opening NFL Week 10 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Nov. 6, 2025.

Vaughn Dalzell breaks down whether or not Jonathan Taylor is good bet to become the first running back to win MVP since 2012.

Perhaps to the surprise of some, the New England Patriots and Denver Broncos, who are both 6-2 and atop their respective divisions with second-year quarterbacks at the helm, enter Week 9 with the longest active winning streaks in the NFL.

The Carolina Panthers and Green Bay Packers meet Sunday for a Week 9 game at Lambeau Field in Green Bay, Wisconsin. Kickoff is scheduled for 1 p.m. ET

Is it time for the struggling Cleveland Browns to start Shedeur Sanders? And when will the drama end between A.J. Brown and the Eagles? Here's who is hot and cold entering Week 9.