Week 8 of the 2025 NFL season was a historic one for betting favorites, as they went 11-2 against the spread to tie the best ATS mark for favorites in any one week since the 1970 AFL/NFL merger. In Week 9, the underdogs got their revenge in a big way.

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Arizona Cardinals and Seattle Seahawks.

Get the opening NFL Week 10 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Nov. 6, 2025.

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -143 money line favorites (risk $143 to win $100),

Two-time top-five SuperContest finisher “Dr. Alan” Dumond analyzes every NFL Week 9 Sunday and Monday game and makes predictions for each matchup.

Few events bring as much excitement to Americans as the NFL season. 2025 has many prevalent storylines, but which bets should we be targeting in Week 9?

The Lions are the most-bet team by both tickets and money at one sportsbook heading into their home game against the Vikings.

SportsLine expert Jeff Hochman breaks down his top money line parlays for favorites and underdogs for Week 9 of the NFL season

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