To investigate the effect of SHP2 on the STAT3/TET3/HOXB2 signaling pathway in osteosarcoma, and its role in the proliferation, migration and invasion of osteosarcoma cells. First, bioinformatics ...

Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival rate following metastasis onset. Nerve growth factor (NGF) has been implicated in the metastasis and progression ...

Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes. Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and ...

Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a ...

Researchers have been able to identify at least three distinct subtypes of a rare type of bone cancer for the first time, which could transform clinical trials and patient care. While genetic ...

The findings explain the unique biology that causes this tumor type to be so aggressive and the high levels of genomic instability observed in osteosarcoma cancer cells. The team also made advances in ...

Large-scale analysis of patient cohorts reveals a novel mechanism driving osteosarcoma, an aggressive paediatric bone cancer. The researchers show that this mechanism occurs in approximately 50% of ...