A research team at Ruhr University Bochum, Germany, has identified a previously unknown cellular mechanism crucial to the replication of coronaviruses: c-Jun N-terminal kinase (JNK) is activated ...

A recent iScience study finds that the swine acute diarrhea syndrome coronavirus (SADS-CoV) promotes autophagy to maintain its replication inside host cells. More specifically, the virus downregulates ...

A schematic diagram showing the significant contribution of SCoV2-induced altered mitochondrial dynamics and mitochondrial EGFR translocation in sustaining viral propagation. First, SCOV2 RNA and ...

Research appearing in the Journal of Medicinal Chemistry shows for the first time SARS-CoV-2, the virus responsible for COVID-19, can be inhibited from replicating in living cell cultures using a ...

High-resolution images provide clarity into how viral proteins are separated by a protease, an important step during virus replication that is targeted by an approved COVID-19 drug. UNIVERSITY PARK, ...

Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to produce viral proteins and thus spread more quickly. This is the main ...

This article and associated images are based on a poster originally authored by Cristina Alli, Chiara Soldati, Ottavia Cecchetti, Monica Bisbocci, Sara Pugliese, Mauro Cerretani, Elisa Beghetto, Marta ...