Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders. These drugs were ...

Octopuses and squids carry the largest nervous systems of any invertebrate, and roughly two-thirds of an octopus’s neurons ...

To transmit excitatory signals, nerve cells mostly use glutamate as a neurotransmitter. To detect these transmitter signals, ...

Understanding the network topology of a cluster of diverse neurons acting in concert requires a detailed expression map of ligand–receptor pairs involved in cell–cell communication. The neuropeptide ...

Cells have surface receptors that couple to proteins and other molecules to initiate or inhibit certain behaviors.

Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell–cell communication (CCC) is essential for growth, development, ...

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled receptors in living cells actually respond to activating substances. The ...

Animals depend on their sense of smell to locate food, identify mates and evade danger. In mammals, olfactory perception typically relies on G protein–coupled receptor (GPCR) pathways. Insects, by ...

A new AI tool that models how variations in peptides change T cell receptor binding could help design immunotherapies with fewer off-target effects. Protein complexes that adorn the surface of T cells ...

A rodent study demonstrated that ASC39 activated the key human amylin receptor (hAMY1R) with potency similar to eloralintide ...

Our body receives and processes a vast number of signals. Chemical signals serve as guidance cues and ensure, for example, that immune cells arrive exactly where they are needed. Many vital processes ...

BUFFALO, N.Y. – Drugs that act on NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment consciousness, are key for treating neuropsychiatric disorders.