Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a protein and alter its function. A team at HZB has now investigated the Nsp1 ...

UCSF researchers designed new drug candidates that potently block MPro, a viral enzyme that's crucial for SARS-CoV-2 replication. One of these drug candidates, AVI-4516, is shown (center) bound to the ...

Coronaviruses not only use the machinery of the human cells they infect: they modify them to achieve optimal conditions to ...

(A) A comprehensive analysis of caffeine binding to one of the spike proteins; (B, C) Caffeine interacts with critical amino acids in the SARS-CoV-2 S protein’s receptor-binding domain (RBD), ...

The RNA-based Nipah virus, which causes acute respiratory illness and fatal encephalitis, can be transmitted from fruit bats to humans directly or indirectly via pigs or horses. Researchers at Wuhan ...

Findings reveal coronaviruses exploit stress-linked tRNA modifications, enhancing translation efficiency and offering insights for antiviral drug development.

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2. Although vaccines helped control the spread of the virus, the emergence of new variants continues ...

FDA has approved Phase II trial for IN002.5.1 SARS-CoV-2 mRNA vaccine. This approval paves the way for the development of combined respiratory virus vaccines. We are thrilled with the FDA's approval ...

Many proteins have a complex architecture that enables biological functions. Molecules can bind to specific sites on a ...