The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

The cryo-EM structure of Dom34–ΔN-Hbs1–SL-RNC showed no density at the mRNA entry site, further confirming the assignment of the Hbs1 N terminus (Supplementary Figs. 3d and 6b).

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

For the most part, self-amplifying mRNA is very similar in structure to conventional, synthesized mRNA. Both are made up of a genetic sequence that encodes the desired viral antigen.

Good news for quality control of messenger RNA (mRNA) medications Cutting edge mass spectrometry meets software analysis to elucidate mRNA structure ...

Hydrogel spheres compose a Microporous Structure for localized mRNA delivery. These Microporous Structures ensure the protection and effective delivery of mRNA into cells, enhancing cell viability ...

The structure of human EPO. a, the primary structure of EPO (ref 1 )(https://doi: 10.1126/sciadv.1500678); b, the 3D structure of EPO. What are LNP-mediated mRNA drugs?

mRNA therapies are quite simple, ... They’ve also turned to E. coli to manufacture mRNA therapies more cheaply and hope to study how the sequence and structure of mRNA affects manufacturing yields.

This novel mRNA, with comb-like structure, has double-stranded RNA in the shape of comb teeth, activates immune cells, and demonstrates high anti-tumor effects in experiments using melanoma and ...

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).