Because of this flexibility, the 30 to 40 tRNAs present in a cell can "read" all 61 codons in mRNA. The opposite end of the folded structure, which is the 3' end of the tRNA, binds to its ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

(Image: ttsz/iStock via Getty Images Plus) The Role of mRNA in Gene Expression Messenger RNA is an essential component of the gene expression process, which involves the conversion of genetic ...

Translation Begins After the Assembly of a Complex Structure The translation of mRNA begins with the formation of a complex on the mRNA (Figure 4). First, three initiation factor proteins (known ...

A research team from POSTECH has developed a biodegradable polymer-based delivery system that efficiently transports mRNA.

RNA breaks destined for repair are inflicted by sequence-specific or structure-specific endoribonucleases during physiological RNA processing (e.g. tRNA splicing; kinetoplast mRNA editing) and under ...

In a significant leap forward in the realm of regenerative medicine, a team at the Terasaki Institute for Biomedical Innovation has introduced a pioneering approach to mRNA therapy using ...

Crossing the BBB is difficult because the structure has evolved to keep out virtually any dangerous or foreign molecules, including most medicines; mRNA molecules are too large to penetrate the ...

The mRNA cap structure is an important point of consideration for the immunogenicity of your mRNA-based product. Whereas legacy cap analogs produce a Cap0 structure and are recognized by the immune ...