Ubiquitin is a protein that is present throughout cellular tissues in eukaryotic organisms which plays a regulatory role in the processes of other proteins and is a versatile molecular signal. First ...

Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...

ITCH is an important regulator of SARS-CoV-2 life cycle, coordinating ubiquitination, assembly, autophagosome-mediated secretion, and spike stability, highlighting ITCH as a promising therapeutic ...

Researchers have unveiled the crystal structures of UBA6 in complex with either ATP or the ubiquitin-like protein FAT10. These results provide the foundation to study the individual roles of UBA6 ...

In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and ...