Get the opening NFL Week 10 odds with point spreads, Over/Unders, and football moneylines for every matchup starting on Nov. 6, 2025.

In Week 10, the Kansas City Chiefs are scheduled for the annual bye week. All three of the AFC West foes will be playing, however. The Broncos are coming off an 18-15 victory on the road over the Houston Texans in Week 9. The Raiders came up short in a 30-29 overtime loss to the Jacksonville Jaguars on Sunday.

Week 8 saw just one game decided by single-digits, but should that have an impact with your Week 9 NFL predictions? The NFL odds have a mix of slim NFL lines and wide ones, as there are five games with a spread of under a field goal, as well as five ...

That’s right: Drake Maye is currently third on the MVP betting board (+500) and Jonathan Taylor — a running back! — is in eighth (+1800). That puts them ahead of luminaries like Jalen Hurts, Jared Goff and Lamar Jackson.

Both teams look to bounce back from recent losses as Chicago (4-3) visits Cincinnati (3-5) at Paycor Stadium with kickoff at 1 p.m. ET on CBS.