Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

Muraki, M ∙ Ohkawara, B ∙ Hosoya, T ∙ et al.

How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing.

Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic ...

Mutually exclusion exons (MXE): One of two exons is retained in mRNA splicing, but not both. Alternative 5' splice site (A5SS): An alternative 5' splice junction (donor site) is used that changes the ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

Alternative techniques, for example using experimental procedures ... out in order to identify previously know mutations which had been found to affect pre-mRNA splicing. Out of the 67 mutations ...

Output: For each alternative splicing event, SURVIV outputs the P-values that evaluate ... SURVIV: Survival Analysis of mRNA Isoform Variation. Nature Communications. (In press).

For further information, see figure 3B. The proteomes of both healthy and diseased tissues attain an extra level of complexity by alternative splicing that may fall into one of four major categories ...