The simplest way to decipher the code would be to start with an mRNA molecule of known sequence, use it to direct the synthesis of a protein, and then determine the amino acid sequence of the ...

In a new paper in Nano Letters, the researchers demonstrate how peptides—short strings of amino acids—can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to ...

Ribosomes read the mRNA sequence, and as the ribosome moves along the mRNA, amino acids are linked together in the order specified, forming a growing protein chain. A change in the translational ...

Within the ribosome, the mRNA and aminoacyl-tRNA complexes are held together closely, which facilitates base-pairing. The rRNA catalyzes the attachment of each new amino acid to the growing chain.

In trials at University College London Hospitals (UCLH), an ASO is being used to target the mutated gene that results in the ...

Grozdanov explained that alternative polyadenylation is an RNA-processing mechanism that determines how an mRNA amino acid sequence ends by selecting specific sites called polyadenylation sites.

Lots of it. Many ribosomes can be working on a single strand of mRNA at once. Protein synthesis isn't a slow process, either. A protein chain 400 amino acids long can be assembled in 20 seconds!

The small subunit had gone away; the mRNA had gone away. We thought the ribosome was completely in destruction mode. So why was it bringing in a tRNA with an amino acid ready to be added on to the ...

A study published in PNAS reveals how a bacterial pathogen coordinates N-acetylneuraminic acid (Neu5Ac) metabolism at the ...

The newly formed strand of mRNA is now ready to leave the nucleus ... Peptide bonds form between the adjacent amino acids to finalise the structure.

A study reveals how Salmonella enterica leverages a small RNA, ManS, to regulate Neu5Ac metabolism and adapt to the host intestine. ManS originates from the 3′ UTR of mRNA via noncanonical RNase III ...