DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

Wang, Chen, and their team wanted to take on the complex challenge of designing an mRNA structure that could be stable, active, and produce sustained therapeutic effects in low doses.

For the most part, self-amplifying mRNA is very similar in structure to conventional, synthesized mRNA. Both are made up of a genetic sequence that encodes the desired viral antigen.

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Simply put, Wang’s lab wanted to design an mRNA structure that could be stable, active, and produce sustained therapeutic effects at low doses.

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

DNA double helix means that the two-stranded structure of DNA structure is common knowledge, RNA’s single-stranded format is not as well known. RNA can form into double-stranded structures, such as ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

Good news for quality control of messenger RNA (mRNA) medications Cutting edge mass spectrometry meets software analysis to elucidate mRNA structure ...

Hydrogel spheres compose a Microporous Structure for localized mRNA delivery. These Microporous Structures ensure the protection and effective delivery of mRNA into cells, enhancing cell viability ...

A cap structure, for example, stabilizes mRNA, which is required to translate the intended proteins. Nonetheless, adding the cap can be complex and expensive.