EMBO Press

Solid trouble: tau and TDP-43 interaction in aggregation and pathology

Both microtubule-binding protein tau and RNA-binding protein TDP-43 have been associated with neurodegenerative diseases, such as Alzheimer’s disease, including in co-pathological deposition with each ...
EMBO Press

A personal journey through academia as a neurodiverse scientist

I recently participated in a collection of interviews for an excellent piece by Julian Nowogrodzki, who presented scientists with ADHD and how we navigate the challenges of academia (Nowogrodzki, 2025 ...
EMBO Press

Fluorescent protein and peptide tags alter condensate formation and dynamics in vivo and in vitro

Protein and peptide tags can profoundly alter condensation in a tag- and protein-specific manner, both in cells and in vitro, ...
EMBO Press

From microscopes to maps: enabling a new era of open and reproducible data sharing in intravital imaging

In this issue of The EMBO Journal, Pizzagalli and colleagues present proof-of-principle analyses of immune cell motility ...
EMBO Press

CTRP9 engages AdipoR1 and promotes T cell glycolysis and immunity

AdipoR1 selectively recognizes adipokine ligands, differentially shaping T-cell immune outcomes. CTRP9 engages AdipoR1 to ...
The EMBO Journal

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

Keap1 is a BTB‐Kelch substrate adaptor protein that regulates steady‐state levels of Nrf2, a bZIP transcription factor, in response to oxidative stress. We have determined the structure of the Kelch ...
The EMBO Journal

Predicting cellular responses to complex perturbations in high‐throughput screens

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The compositional perturbation autoencoder ...
The EMBO Journal

Glutamylation of centrosomes ensures their function by recruiting microtubule nucleation factors

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Centrosomes are tubulin-based organelles that ...
The EMBO Journal

The HSP110/HSP70 disaggregation system generates spreading‐competent toxic α‐synuclein species

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The HSP110/HSP70 chaperone system plays key ...
The EMBO Journal

Direct action of endocrine disrupting chemicals on human sperm

A plethora of endocrine disrupting chemicals (EDCs)—omnipresent in food, household, and personal care products—interfere with various human sperm functions and thus might impair fertilization.
The EMBO Journal

Gli1 labels progenitors during chondrogenesis in postnatal mice

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Gli1 + chondrogenic progenitors maintained by ...
The EMBO Journal

PerturbNet predicts single-cell responses to unseen chemical and genetic perturbations

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chemical and genetic perturbations, such as ...