Objectives DNASE1L3 deficiency is a rare monogenic cause of early-onset SLE and hypocomplementaemic urticarial vasculitis ...

Objective This study aimed to compare 25-hydroxyvitamin D (25-(OH)D) levels and peripheral lymphocyte subsets between ...

Objective In phase II and III trials, anifrolumab, a human monoclonal antibody that binds type I interferon receptor subunit 1, has shown efficacy in adults with moderate to severe SLE. We evaluated ...

Lupus is a complex heterogeneous disease characterised by autoantibody production and immune complex deposition followed by damage to target tissues. Animal models of human diseases are an invaluable ...

Background The short-term and long-term outcome of inflammatory neuropsychiatric SLE (NPSLE) with immunosuppressive treatment is largely unknown. We used clinical data from our tertiary referral ...

Objective To estimate the prevalence of organ damage (damage) and flare and to examine longitudinal associations between flares and subsequent damage accrual, in patients with systemic lupus ...

The case for early biologic therapy in systemic lupus erythematosus (SLE) is intuitively appealing but requires closer scrutiny. First, ‘early’ is poorly defined with UK survey data showing a mean ...

Objectives Composite criteria/indices are presently used to diagnose and monitor patients with systemic lupus erythematosus (SLE). Biomarkers for these purposes would be helpful in clinical practice.

Objectives Systemic lupus erythematosus (SLE) is a chronic autoimmune disease involving dysregulated innate and adaptive immunity, with autoreactive B and T cells being central to its pathogenesis.

Objectives Cardiovascular disease is a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE), largely driven by endothelial dysfunction. Belimumab, a monoclonal antibody ...

Systemic lupus erythematosus (SLE) is a profoundly heterogeneous disease in which clinical phenotype emerges from the interplay of autoantibody profiles, organ involvement, cytokine signatures, ...

In systemic lupus erythematosus (SLE), the term ‘immune reset’ is seductive but potentially too mechanical: it implies that autoimmunity can be switched off and the immune system returned to a ...