A machine-learning method predicts whether a genetic variant is pathogenic and affects certain human tissues. The ...

How the hydrolytic activity of mitochondrial ATP synthase is modulated during brown adipose tissue (BAT) thermogenesis ...

MDA5 is a critical cytoplasmic RNA sensor capable of triggering type I interferon pathways. This study shows that the E3 ...

K Heran Darwin is at New York University Grossman School of Medicine and a regular columnist for EMBO reports.

Metabolic rewiring is essential for osteoclast differentiation and bone resorption. This study shows that glutaminolysis ...

It is boomtime for metabolism and metabolomics research. One hundred years after Otto Warburg put metabolism at the core of ...

The inhibition of ERK5 is a potential complementary strategy for countering FAK inhibitor resistance in patients with lung ...

Changing nutrient environments challenge cells as they affect both protein biosynthesis and cell cycle length. This work ...

Human papillomavirus (HPV) and hyperactivated YAP1 form a YAP1-HPV oncogenic alliance to drive the malignant transformation ...

FAO is catalyzed by the mitochondrial trifunctional protein (MTP) and, if overloaded, generates ROS. ROS are boosted during ...

Co-expressing NPY and its inhibitory receptor Y2 in excitatory hippocampal cells allows inhibitory autoregulation of ...

However, an unfortunate feature of biochemistry and its contemporary teaching in schools and universities is its emphasis on ...