Increasing BDNF in the brain helps with memory, cognition, resilience, and even wisdom. Simple lifestyle changes can boost it ...

Why does ketamine wear off so fast? New research identifies the NOX-1 enzyme as a key target to prolong ketamine’s antidepressant effects for treatment-resistant depression.

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers ...

Treatment-resistant depression affects a large proportion of people with major depressive disorder, and while ketamine offers ...

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond ...

While preclinical studies have long suggested that ketamine's antidepressant effects depend on AMPAR activity, this study provides the first direct evidence supporting this mechanism in humans. The ...

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and approximately 30% of patients develop treatment-resistant depression (TRD), a condition that does not respond ...

Positron emission tomography (PET) images using the novel tracer [¹¹C]K-2 visualize cell-surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) density in the living human brain ...

Psychedelic-assisted therapy is showing promise in managing conditions like PTSD and treatment-resistant depression.

As someone who has been involved in psychiatric drug development and clinical strategy for more than two decades, I believe ...

CAMBRIDGE, MA -- When patients undergo general anesthesia, doctors can choose among several drugs. Although each of these drugs acts on neurons in different ways, they all lead to the same result: a ...

ACADIA Pharmaceuticals (NASDAQ:ACAD) executives discussed upcoming clinical readouts and pipeline priorities during the ...