This paper addresses the important question of quantifying epistasis patterns, which affect the predictability of evolution, by reanalyzing a recently published combinatorial deep mutational scan ...

Some genetic diseases do not follow a simple pattern of inheritance and exhibit phenotypic variation. This can be explained as a monogenic disorder that is being affected by the action of nonlinked ...

Discover the importance of vision, genetic eye disorders, and RNA-based therapies for precision treatment in India and ...

Researchers developed a technique to gain a deeper understanding of ribosome function and their cooperative behaviors.

The companies will work together by using the codon-optimized BBS1 AAV9 vector to minimize the vision loss caused by the ...

The gene has a variably sized swath of one repeating codon, CAG, tucked into its sequence. People who inherit more than about 35 repeats are very likely to develop the disease in middle age ...

Results: We found that the SER varies across the genome and that the variation is primarily influenced by codon-related factors. Moreover, the conserved motifs identified based on the SER were found ...