Now comes the hard part for Kyle Shanahan — devising a game plan without Deebo Samuel and Christian McCaffrey.

SANTA CLARA, Calif. — The San Francisco 49ers have played games without Deebo Samuel Sr. in the last year and a half. And ...

Ask teammates about McCaffrey and many will compare his "gravity" to that of Golden State Warriors guard Stephen Curry. The ...

Alvin Kamara surpassed Christian McCaffrey in career touchdowns scored, ranking sixth-best among active players. Klint Kubiak ...

There are plenty of questions swirling around with the San Francisco 49ers right now with Christian McCaffrey on the Injured ...

When Christian McCaffrey went down, the 49ers could take solace in the fact that they had another versatile and dynamic ...

Not only will San Francisco 49ers star running back Christian McCaffrey miss another game, but he's in jeopardy of being ...

San Francisco 49ers star running back Christian McCaffrey could be out for six weeks or more due to his calf soreness and ...

San Francisco had its toughest practice of the week Thursday and McCaffrey was dealing with pain afterward, Shanahan said.

The San Francisco 49ers are without running back Christian McCaffrey for at least four weeks. A report from NFL Media’s Ian ...

San Francisco 49ers star Christian McCaffrey could miss more than the minimum of four games required on injured reserve, ...

The San Francisco 49ers have ruled out Christian McCaffrey for Week 2 vs. the Minnesota Vikings — and potentially longer.