In a pivotal randomised controlled trial, the BNT162b2 mRNA vaccine (tozinameran, Pfizer–BioNTech) showed 95% or greater efficacy against symptomatic and severe COVID-19 disease due to SARS-CoV-2. 1 ...

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Gene editing, mRNA technology for developing vaccines and cognitive behavioral therapy rank among the most recognized scientific discoveries of the past 75 years.