In a pivotal randomised controlled trial, the BNT162b2 mRNA vaccine (tozinameran, Pfizer–BioNTech) showed 95% or greater efficacy against symptomatic and severe COVID-19 disease due to SARS-CoV-2. 1 ...

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Scientists have discovered that the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact on how well our ...

Using capillary gel electrophoresis, researchers from the National Institute of Health Sciences in Kanagawa, Japan studied the factors that optimize chain-length distribution analysis of messenger RNA ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big ...

When mRNA is used to create vaccines, mRNA carries instructions into our cells to build proteins that form part of a virus, such as the spike protein of the Covid virus. The body’s cells make these ...