DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

In this valuable study, Kumar et al., provide evidence suggesting that the p130Cas drives the formation of condensates that sprout from focal adhesions to cytoplasm and suppress translation. Pending ...

Gene editing, mRNA technology for developing vaccines and cognitive behavioral therapy rank among the most recognized scientific discoveries of the past 75 years.

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Scientists have discovered that the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact on how well our ...

Using capillary gel electrophoresis, researchers from the National Institute of Health Sciences in Kanagawa, Japan studied the factors that optimize chain-length distribution analysis of messenger RNA ...

Meghan McCain, the former co-host of “The View,” made headlines when she posted to social media recently in support of a “detox” supplement to be taken after Covid-19 vaccination or infection.

This hierarchical structure of synonymous codons is crucial for mRNA’s functional roles, particularly in therapeutics like vaccines and gene therapies. Researchers from Johnson & Johnson and the ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

Wang, Chen, and their team wanted to take on the complex challenge of designing an mRNA structure that could be stable, active, and produce sustained therapeutic effects in low doses.