The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Wang, Chen, and their team wanted to take on the complex challenge of designing an mRNA structure that could be stable, active, and produce sustained therapeutic effects in low doses.

For the most part, self-amplifying mRNA is very similar in structure to conventional, synthesized mRNA. Both are made up of a genetic sequence that encodes the desired viral antigen.

Simply put, Wang’s lab wanted to design an mRNA structure that could be stable, active, and produce sustained therapeutic effects at low doses.

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

Good news for quality control of messenger RNA (mRNA) medications Cutting edge mass spectrometry meets software analysis to elucidate mRNA structure ...

Hydrogel spheres compose a Microporous Structure for localized mRNA delivery. These Microporous Structures ensure the protection and effective delivery of mRNA into cells, enhancing cell viability ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

Mammalian Oocytes Store mRNA in Newly Found Membraneless Structure. The findings answer the longstanding question of where these cells hold the mRNA needed to cope with the transcriptional halt ...