When mRNA is no longer needed, ... In doing so, they reveal an important function of the supercomplex: connecting the translation of an mRNA by the ribosome and its destruction through the exosome.

The translation of mRNA begins with the formation of a complex on the mRNA (Figure 4). First, three initiation factor proteins (known as IF1, IF2, and IF3) bind to the small subunit of the ribosome.

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

Here, the mRNA sequence is decoded in the process of translation into an amino acid sequence, the basic building blocks of proteins, and synthesized into amino acid chains. SKI complex: consists of ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

Research led by Duke University, Durham, has discovered a situation-dependent traffic jam in mRNA translation caused by RNA hairpins leading to higher translation of upstream start codons (uAUGs).

By unraveling the dynamics of mRNA translation, researchers can gain deeper insights into cellular processes and the role of protein synthesis in health and disease. RELATED TOPICS.

The main hurdles for mRNA clinical translation are the stability, translation efficiency, and immunostimulatory potential of exogenous mRNA.

Professor Hirohide Saito and his research team have developed a new approach to control mRNA translation using Cas proteins, thus expanding the variety of mRNA switches and making it easier to ...

In combination with RNA sequencing to characterize all mRNA, they used a technique called Ribo-seq to capture and sequence mRNA that are actively undergoing translation. 19 While most proteins are ...