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Cancer Research1d
Special Series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI
Publishing in July 2025 to coincide with the AACR Special Conference in Cancer Research: Artificial Intelligence and Machine Learning, the series will continue through December 2025! Technological ...
Cancer Research6d
American Association for Cancer Research
This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license. This work is licensed under a Creative Commons ...
Cancer Research6d
The Dynamically Evolving Cell States and Ecosystem from Benign Nevi to Melanoma
1Hunan Key Laboratory of Skin Cancer and Psoriasis, Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Xiangya Hospital, Central South University, Changsha, China ...
Cancer Research6d
Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points–Based Framework
1Department of Pediatrics III, University Children’s Hospital Essen, University of Duisburg-Essen, Essen, Germany. 2Department of Otorhinolaryngology & Head/Neck Surgery, University Hospital ...
Cancer Research7d
METTL3 Inhibition Restores PD-L1 Expression and CD8
1Key Laboratory of Dunhuang Medicine and Transformation at Provincial and Ministerial Level, Gansu University of Chinese Medicine, Lanzhou, China. 2Provincial-Level Key Laboratory for Molecular ...
Cancer Research8d
Cholesterol Metabolism Dictates Secondary Organ Colonization in Pancreatic Cancer
Major Finding: PCSK9 regulates cholesterol uptake and controls the trajectory of metastasis to secondary organs in pancreatic ductal adenocarcinoma (PDAC). Concept: Cholesterol uptake supports ...
Cancer Research8d
T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-Selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma
1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. 2Abramson Cancer Center and Abramson Family Cancer Research Institute, University of ...
Cancer Research8d
Integrative Immune Signature of Complementary Circulating and Tumoral Biomarkers Maximizes the Predictive Power of Adjuvant Immunotherapeutic Benefits in High-risk Melanoma
1Department of Cutaneous Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. 2Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida. ...
Cancer Research13d
SSRIs Elevate Intratumoral Serotonin and Enhance Antitumor Immunity
Major Finding: Serotonin transporter depletes intratumoral serotonin which dampens CD8 + T-cell antitumor immunity. Concept: Serotonin transporter inhibition with SSRIs drives T-cell antitumor ...
Cancer Research15d
American Association for Cancer Research
This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license. Cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy is the ...
Cancer Research15d
Three Articles from the NCI’s Preclinical Chemoradiotherapy Testing Consortium
Radiation Research Program, Division of Cancer Treatment and Diagnosis, NCI, Bethesda, Maryland. *Corresponding Author: Jeffrey C. Buchsbaum, Radiation Research Program, Division of Cancer Treatment ...
Cancer Research15d
Loss of Y Chromosome Weakens T Cells
According to a newly published article, immune cells with a loss of the Y chromosome (LOY) are less equipped to attack cancer cells than their Y chromosome-containing counterparts (Nature 2025 Jun 4 ...