Cancer Research

American Association for Cancer Research

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Cancer Research

AKR1C1 Promotes ADC Resistance by Altering Uptake and Export

Although antibody–drug conjugates (ADC) have transformed the standard of care for patients with metastatic urothelial carcinoma, primary and acquired resistance remain major obstacles to achieving ...
Cancer Research

Pancreatic Cancer Risk Stratification across Diabetes Stages: Development and Internal Validation of a Machine Learning Model

*Corresponding Author: Salman Khan, Department of Internal Medicine, University of Texas Southwestern, 5323 Harry Hines Blvd, Dallas, TX 75390-8558. E-mail: [email protected] ...
Cancer Research

Spatial and Temporal Analysis Characterizes Evolution of Metastatic Lung Cancer

Cancer Discov (2026) 16 (7): OF1.
Cancer Research

Spatially Sussing Out the TME, No Tissue Needed

Cancer Discov (2026) 16 (7): OF1.
Cancer Research

GLP-1 RAs May Prevent Metastatic Progression

Cancer Discov (2026) 16 (7): OF1.
Cancer Research

Age Distinguishes Cancer-Causing Mutations from Positively Selected Bystanders

Cancer Discov (2026) 16 (7): OF1.
Cancer Research

Signaling Under Stress: Targeting the Glucocorticoid Receptor in Cancer

Abstract. Glucocorticoid receptor (GR) signaling is critical to our physiology but is dysregulated in cancer by the pain, psychologic distress, iatrogenic morbidity, and pathology associated with an ...
Cancer Research

Spatially Resolved Molecular Subtyping Uncovers Tumor Progression and Immune Evasion Mechanisms in High-grade Serous Ovarian Cancer

AbstractHigh-grade serous ovarian cancer (HGSOC) is a lethal malignancy characterized by profound intratumoral heterogeneity and immune evasion. Although previous research has identified 4 molecular ...
Cancer Research

Evolutionary Antifragile Therapy Is a Treatment Strategy to Suppress Drug Resistance by Exploiting Dose–Response Convexity

1Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Cancer Research

Targeting KRAS codon 13 mutations using direct combination approaches in non-small cell lung cancer

Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...