Jie Du of Cardinal Health discusses with LCGC International how switching from reversed-phase to hydrophilic interaction liquid chromatography (HILIC) can unmask a hidden excipient artifact mistaken ...

He describes how labs often receive samples with vague instructions to simply "find out what PFAS are in it," when what's ...

Sample preparation takes the spotlight as the panel debates the trade-offs between direct injection and solid-phase extraction (SPE). David Megson recalls trace-level analysis in complex matrices from ...

Bryan Vining introduces one of the most persistent problems in per- and polyfluoroalkyl substances (PFAS) work: background contamination. Because PFAS compounds are so ubiquitous, he notes, measuring ...

Bryan Vining notes that early PFAS concern centered on eight-carbon compounds like perfluorooctanoic acid (PFOA) and ...

Technique selection hinges on volatility/polarity; LC‑HRMS typically initiates characterization for nonvolatile/semi-volatile features, while GC‑MS can resolve ...

uMRM links untargeted MS/MS acquisition to quantitative workflows, prioritizing experimentally derived fragmentation over purely in silico predictions. Empirical controls and noise-filtering ...

Shimadzu expanded its eTOC portfolio with the TOC-1000e S to continuously quantify trace organic contamination in ultrapure ...

Ambient ionization via rapid evaporative ionization MS provided near-real-time lipid fingerprints, complementing hyphenated ...

Sensor gas chromatography (GC) determines whether water chasers change alcohol metabolism. Hangovers can make it harder to safely drive a car or work in jobs that require careful attention, on top of ...

A controlled-degradation/RPLC–HRMS pipeline enables sequence-level PLGA microstructural readouts by converting >100 kDa polymers into <~1–2 kDa oligomers suitable ...