To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

During protein synthesis, or translation, genetic information transcribed in the cell's mRNA directs the stringing together ...

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions.

A glimpse into nature's looking glass -- to find the genetic code is reassigned: Stop codon varies widely Date: May 22, 2014 Source: DOE/Joint Genome Institute ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from ...

As an example, the codon CGA instructs a tRNA to transfer the amino acid arginine to the ribosome. A common genetic mutation converts CGA to UGA, turning an arginine codon into a premature stop codon.

This results in a less efficient stop codon being found more often than would be expected, mostly in the less commonly used genes. In contrast, in species with large, ...

Alltrna has raised another $109 million in a series B to fund the Flagship Pioneering biotech's mission to "stop codon disease" with potential benefits for a range of genetic diseases caused by ...

It basically put a stop sign, called a stop codon, toward the beginning of the KEAP1 gene. Stop codons generally signal where a gene ends, so having one at the start would "break" the gene.