The new CBC-ALYREF structure revealed molecular insights into the ALYREF-mediated recruitment of mRNA export machinery to the 5' end of nascent mRNA transcripts. The structure, along with ...

The cryo-EM structure of Dom34–ΔN-Hbs1–SL-RNC showed no density at the mRNA entry site, further confirming the assignment of the Hbs1 N terminus (Supplementary Figs. 3d and 6b).

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Structure of mRNA initiation complex could give insight into cancer and other diseases. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2020 / 09 / 200903145025.htm.

Decapping is catalyzed by Dcp2, a bilobed hydrolase of the Nudix family 3,4,5, which hydrolyzes the mRNA 5′-cap structure, thereby releasing m 7 GDP and a 5′-monophosphorylated mRNA.

Researchers from Tokyo Metropolitan University and RIKEN CSRS have developed a new analytical platform based on liquid chromatography, mass spectrometry and software analysis that quantifies the ...

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

For the most part, self-amplifying mRNA is very similar in structure to conventional, synthesized mRNA. Both are made up of a genetic sequence that encodes the desired viral antigen.

The team used an mRNA that lacked a start codon so that it would be trapped in the act of scanning. While big for a biological machine, you could fit about 3,000 of these complexes across the width of ...

When the final Phase 3 data came out last November showing the mRNA vaccines made by Pfizer/BioNTech and Moderna were more than 90% effective, Dr. Anthony Fauci had no words. He texted smiley face ...

Messenger RNA (mRNA) is having a moment. This year, hundreds of millions of people will receive shots of the Pfizer-BioNTech or Moderna vaccines for COVID-19.The crucial ingredient in each ...

The structure of human EPO. a, the primary structure of EPO (ref 1 )(https://doi: 10.1126/sciadv.1500678); b, the 3D structure of EPO. What are LNP-mediated mRNA drugs?