The final week of the year features an eclectic group of games, including five divisional contests, five favorites of at least six points, and one matchup of rookie quarterbacks. No. 2 pick Jayden Daniels and the Commanders are favored by 3.

The 49ers have nothing to play for other than pride at this point. They're facing a Lions team that has the best record in the NFC but hasn't even clinched their division yet. Detroit will be playing with a lot on the line, meaning we can expect their very best, even in a game they should have no trouble winning.

Detroit tallied a blowout road victory over the Chicago Bears in Week 16, while San Francisco fell to the Miami Dolphins on the road last week. The Lions can clinch the NFC North