The cellular transcription, mRNA processing and export machineries seem to have co-evolved to allow spatiotemporal coupling of these processes. Here, the author reviews recent insights into the ...

Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

But, as scientists look to model every aspect of mRNA processing, publicly available data on tangential flow filtration (TFF) is noticeably absent.

A Closer Look At mRNA Process Development Challenges. A more detailed examination of mRNA process development (Figure 1) uncovers several areas for improvement across multiple steps.

The mRNA market is projected to reach $63.28 billion by 2025, indicating an all-time high global demand for mRNA vaccines and therapeutics. Now more than ever, robust process development and ...

RNA methylation. Of the ~100 post-transcriptional chemical modifications to RNA known, N 6-methyladenosine (m 6 A) is the most prevalent modification in mRNA. Although described over 40 years ago, ...

However, while working in the late Susan Lindquist’s lab at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, Khurana turned up connections to mRNA translation and ...

The need for such infrastructure has been made clear by this pandemic. Because mRNA and adenovirus tech is so new, the government and industry have had to put together the infrastructure to ...

Creating mRNA with an all-chemical process may allow for customized mRNA vaccines. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2022 / 06 / 220607120959.htm ...

Moderna said Wednesday that its experimental mRNA-based seasonal flu vaccine generated a stronger immune response against four strains of the flu virus than a currently marketed vaccine in a Phase ...