How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

More information: Prashant Bhat et al, Genome organization around nuclear speckles drives mRNA splicing efficiency, Nature (2024). DOI: 10.1038/s41586-024-07429-6 Provided by California Institute ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Long-separated twins: At the crossroads of evolution EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on ...

Long-separated twins: at the crossroads of evolution EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus ...

In a recent article, he showed that when genes are preferentially positioned near speckles, mRNA splicing is significantly more efficient. 4 “It’s huge for the RNA processing field, because now it ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

Long-separated twins: at the crossroads of evolution EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus ...