The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component ...

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Gene editing, mRNA technology for developing vaccines and cognitive behavioral therapy rank among the most recognized scientific discoveries of the past 75 years.

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Using capillary gel electrophoresis, researchers from the National Institute of Health Sciences in Kanagawa, Japan studied the factors that optimize chain-length distribution analysis of messenger RNA ...

This hierarchical structure of synonymous codons is crucial for mRNA’s functional roles, particularly in therapeutics like vaccines and gene therapies. Researchers from Johnson & Johnson and the ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

Wang, Chen, and their team wanted to take on the complex challenge of designing an mRNA structure that could be stable, active, and produce sustained therapeutic effects in low doses.

Simply put, Wang’s lab wanted to design an mRNA structure that could be stable, active, and produce sustained therapeutic effects at low doses.