The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self ...

In a pivotal randomised controlled trial, the BNT162b2 mRNA vaccine (tozinameran, Pfizer–BioNTech) showed 95% or greater efficacy against symptomatic and severe COVID-19 disease due to SARS-CoV-2. 1 ...

DOPE-Cx can form a special structure called a "cubic phase," which helps overcome a major challenge in mRNA delivery by LNPs: endosomal escape. LNPs are taken into the cell in the form of endosomes, ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

Gene editing, mRNA technology for developing vaccines and cognitive behavioral therapy rank among the most recognized scientific discoveries of the past 75 years.

Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Scientists have made a discovery that has the potential to pave the way to more efficient vaccine and mRNA drug delivery.

Using capillary gel electrophoresis, researchers from the National Institute of Health Sciences in Kanagawa, Japan studied the factors that optimize chain-length distribution analysis of messenger RNA ...

Scientists have discovered that the internal shape of tiny drug-delivery particles—called lipid nanoparticles—has a big ...