Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Translation is the process by which a protein is synthesized by the ribosome, using a messenger RNA (mRNA) template. tRNA modifications are key regulators of translational reprogramming, although ...

Our study progresses from the rational design of polyplex micelles to the mechanistic elucidation of mRNA degradation, revealing RNase infiltration—rather than carrier dissociation—as the ...

An mRNA that produces a receptor protein to detect disease signals, An mRNA that makes a regulatory protein to control translation, A therapeutic mRNA that encodes the protein drug itself.

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...